When deploy some application servers which require a high IO performance (like Exchange, Database server) on VMware ESXi, It is common to place the data on the physical RDM (Raw Device Mapping). To backup such VM, you have to explicitly tell TSM to exclude the physical RDM and independent disks from the backup. Otherwise, the backup job will fail. To allow TSM to backup the normal disks (like OS) in such VM, you need to add the option ‘-vmprocessvmwithindependent=yes -vmprocessvmwithprdm=yes’ into the VM backup job.
Example:
update sched vmware Weekly_full_Exchange DAYofweek=Fri Startt=20:00:00 Desc=’Exchange Weekly Full Backup’ OPTions=’-vmfulltype=vstor -vmbackuptype=fullvm -asnodename=DC1 -vmprocessvmwithindependent=yes -vmprocessvmwithprdm=yes -domain.vmfull=”vmfolder=Exchange” -MODE=FULL’
Log:
Jackie Chen's IT Workshop 
do we have any option from client option side to exclude pRDMS and independent disks